Episode 3

full
Published on:

4th Aug 2025

03: FLUORIDE: THE GOLD STANDARD?

Episode Summary

In this episode of Dental Formulator’s Playbook, Dr. Rob and his wife Tami explore the fascinating history and science behind fluoride as the gold standard in preventing tooth decay. They take listeners on a journey through early scientific discoveries, the implementation of water fluoridation, and the evolution of fluoride toothpaste. With a blend of storytelling and science, the episode highlights key breakthroughs, formulation challenges, and the significant impact fluoride has had on dental health over the decades.

From mottled enamel in Colorado Springs to modern toothpaste innovations, Dr. Rob unpacks how fluoride became a cornerstone of preventive dentistry. He also addresses ongoing debates and underscores the importance of staying grounded in evidence-based care.

 Show Highlights: 

  • The history and origins of fluoride use in dental care
  • The discovery and measurement of fluoride in water supplies
  • The development and implementation of community water fluoridation
  • The connection between fluoride and mottled enamel in early-20th-century populations
  • The pharmacokinetics of fluoride and its role in tooth decay prevention
  • The evolution of fluoride mouthwashes and the early formulation challenges
  • The transition from in-office fluoride treatments to accessible at-home products
  • Scientific advancements in toothpaste, especially the synergy between fluoride and abrasives
  • The role of fluoride toothpaste in improving oral health across different age groups
  • Controversies, skepticism, and the importance of evidence-based understanding in fluoride use

 Connect with Dr. Rob (Robert L. Karlinsey, PhD)

🌐 Website: customdentalformulations.com

Next Episode All Episodes Previous Episode

Listen for free

Show artwork for Dental Formulator's Playbook

About the Podcast

Dental Formulator's Playbook
The Dental Formulator’s Playbook is where science meets strategy in the world of oral health innovation. Hosted by Dr. Rob Karlinsey, a seasoned dental researcher and independent formulator, this podcast is your behind-the-scenes pass to what really goes into creating cutting-edge dental products.

Whether you're a dentist, a dental brand, or just someone curious about how toothpaste, rinses, and other oral care products are developed, you'll find practical insights and real-world takeaways in every episode. Dr. Karlinsey keeps it straightforward and engaging—no fluff, just clear, thoughtful explanations based on years of experience in the lab and the industry.

This show is all about helping dental professionals and product developers think differently, make better decisions, and stay ahead of the curve. If you care about science, results, and doing things the right way, you're in the right place.

About your host

Profile picture for Robert Karlinsey

Robert Karlinsey

Dr. Robert L. Karlinsey is a scientist and formulator with almost 20 years’ experience in dental research. He earned a BS in Physics (University of Scranton) and PhD in Chemical Physics (Indiana University), with postdoctoral work in physical chemistry (Indiana University). As a visiting assistant research professor at the Indiana University School of Dentistry, his research led to an impactful encounter with Dr. George Stookey, and shortly thereafter, the formation of Indiana Nanotech, LLC (now known as Custom Dental Formulations, LLC), of which he spearheaded all research and small-scale manufacturing efforts. Dr. Karlinsey is the inventor of Nanotech’s functionalized tricalcium phosphate systems, which continue to help generate over $100MM in global product sales for a major dental manufacturer. As Principal Investigator, his work has received significant funding through Federal (National Institutes of Health), State (Indiana and Texas), and industry grants and contracts. His research in patented calcium phosphate technologies continue to help generate over $100MM in global product sales. Previously, Dr. Karlinsey has served as Chief Scientific Officer at Therametric Technologies, Inc, and adjunct professor of chemistry at the University of Indianapolis.

Dr. Karlinsey addresses clients’ needs in preventive and cosmetic dentistry, including fluoride- and fluoride-free remineralization, antiplaque/gum health, whitening systems, and more. He is actively involved in clinical and laboratory research designs and performance-backed, customized oral care formulation solutions. And, whenever possible, he favors natural, nature-derived, and/or sustainably sourced ingredients